Afficher la couverture 'Polymorphisms in SLCO1B3 and NR1I2 as genetic determinants of hematotoxicity of carboplatin and paclitaxel combination | Mbatchi, Litaty Céphanoée' en grand format
/5

0 avis

Polymorphisms in SLCO1B3 and NR1I2 as genetic determinants of hematotoxicity of carboplatin and paclitaxel combination

Archive ouverte

Mbatchi, Litaty Céphanoée | Schmitt, Antonin | Thomas, Fabienne | Cazaubon, Yoann | Robert, Jacques | Lumbroso, Serge | Brouillet, Jean-Paul | Pourquier, Philippe | Chatelut, Etienne | Boyer, Jean-Christophe | Evrard, Alexandre

Edité par CCSD ; Future Medicine -

International audience. AIM:The goal of our study was to assess the impact of patients' genetic background on their sensitivity to carboplatin/paclitaxel hematotoxicity.PATIENTS & METHODS:Parameters describing sensitivity to neutropenia and to thrombocytopenia of 201 patients were extracted from a previous pharmacokinetic/pharmacodynamics analysis, in order to assess their association with 52 candidates SNPs in 18 genes.RESULTS:Carriers of a T allele of SLCO1B3-rs4149117 were 19% less sensitive to thrombocytopenia than the homozygotes for the G allele (p = 0.00279). Carriers of two copies of the ATG haplotypes of NR1I2-rs1523130, rs3814055 and rs1523127 were 19% less sensitive to thrombocytopenia than those harboring other haplotypes (p = 0.025).CONCLUSION:Our results revealed the importance of SLCO1B3 and NR1I2 in the sensitivity to carboplatin/paclitaxel thrombocytopenia.

Consulter en ligne

Suggestions

Du même auteur

Genetic variations of the xenoreceptors NR1I2 and NR1I3 and their effect on drug disposition and response variability

Archive ouverte | Mbatchi, Litaty Céphanoée | CCSD

International audience. NR1I2 (PXR) and NR1I3 (CAR) are nuclear receptors that are classified as xenoreceptors. Upon activation by various xenobiotics, including marketed drugs, they regulate the transcription level...

Effect of Single Nucleotide Polymorphisms in the Xenobiotic-sensing Receptors NR1I2 and NR1I3 on the Pharmacokinetics and Toxicity of Irinotecan in Colorectal Cancer Patients

Archive ouverte | Mbatchi, Litaty Céphanoée | CCSD

International audience. BACKGROUND AND OBJECTIVES:Nuclear receptors PXR (pregnane X receptor, NR1I2) and CAR (constitutive androstane receptor, NR1I3) are key regulators of irinotecan metabolism, and ligand-dependen...

Population pharmacokinetic model of irinotecan and its four main metabolites in patients treated with FOLFIRI or FOLFIRINOX regimen

Archive ouverte | Deyme, Laure | CCSD

International audience. PurposeThe aim of the present study was to characterize the pharmacokinetics of irinotecan and its four main metabolites (SN-38, SN-38G, APC and NPC) in metastatic colorectal cancer patients ...

Chargement des enrichissements...