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mTOR Activation Underlies Enhanced B Cell Proliferation and Autoimmunity in PrkcdG510S/G510S Mice

Archive ouverte | Moreews, Marion | CCSD

International audience. Autosomal recessive PRKCD deficiency has previously been associated with the development of systemic lupus erythematosus in human patients, but the mechanisms underlying autoimmunity remain p...

Human Naive and Memory T Cells Display Opposite Migratory Responses to Sphingosine-1 Phosphate

Archive ouverte | Drouillard, Annabelle | CCSD

International audience. The role of sphingosine-1 phosphate (S1P) in leukocyte trafficking has been well deciphered in mice but remains largely unaddressed in humans. In this study, we assessed the ex vivo response ...

Novel Potent Selective Orally Active S1P5 Receptor Antagonists

Archive ouverte | Ma, Bin | CCSD

International audience

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