Translational Control of the HIV Unspliced Genomic RNA

0 avis

Translational Control of the HIV Unspliced Genomic RNA

Archive ouverte

Rojas-Araya, Bárbara | Ohlmann, Théophile | Soto-Rifo, Ricardo

Edité par CCSD ; MDPI -

International audience. Post-transcriptional control in both HIV-1 and HIV-2 is a highly regulated process that commences in the nucleus of the host infected cell and finishes by the expression of viral proteins in the cytoplasm. Expression of the unspliced genomic RNA is particularly controlled at the level of RNA splicing, export, and translation. It appears increasingly obvious that all these steps are interconnected and they result in the building of a viral ribonucleoprotein complex (RNP) that must be efficiently translated in the cytosolic compartment. This review summarizes our knowledge about the genesis, localization, and expression of this viral RNP.

Langue: en

Indexation

Consulter en ligne

Consulter le document

Suggestions

Du même auteur

DEAD-box RNA helicase DDX3 connects CRM1-dependent nuclear export and translation of the HIV-1 unspliced mRNA through its N-terminal domain

Archive ouverte | Fröhlich, Alvaro | CCSD

International audience. DEAD-box RNA helicase DDX3 is a host factor essential for HIV-1 replication and thus, a potential target for novel therapies aimed to overcome viral resistance. Previous studies have shown th...

An epitranscriptomic switch at the 5´-UTR controls genome selection during HIV-1 genomic RNA packaging

Archive ouverte | Pereira-Montecinos, Camila | CCSD

During retroviral replication, the full-length RNA serves both as mRNA and genomic RNA (gRNA). While the simple retrovirus MLV segregates its full-length RNA into two functional populations, the HIV-1 full-length RNA was proposed ...

The role of the DEAD-box RNA helicase DDX3 in mRNA metabolism.

Archive ouverte | Soto-Rifo, Ricardo | CCSD

International audience. DDX3 belongs to the DEAD-box proteins, a large family of ATP-dependent RNA helicases that participate in all aspects of RNA metabolism. Human DDX3 is a component of several messenger ribonucl...

Chargement des enrichissements...