NME4/nucleoside diphosphate kinase D in cardiolipin signaling and mitophagy

Archive ouverte | Schlattner, Uwe | CCSD

International audience. Mitophagy is an emerging paradigm for mitochondrial quality control and cell homeostasis. Dysregulation of mitophagy can lead to human pathologies such as neurodegenerative disorders and cont...

The nucleoside diphosphate kinase D (NM23-H4) binds the inner mitochondrial membrane with high affinity to cardiolipin and couples nucleotide transfer with respiration.

Archive ouverte | Tokarska-Schlattner, Malgorzata | CCSD

International audience. Nucleoside diphosphate kinase (NDPK/Nm23), responsible for intracellular di- and triphosphonucleoside homeostasis, plays multiple roles in cellular energetics, signaling, proliferation, diffe...

Use of NME4/NDPK-D to evaluate cancer prognosis

Archive ouverte | Schlattner, Uwe | CCSD