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Histone removal in sperm protects paternal chromosomes from premature division at fertilization

Archive ouverte | Dubruille, Raphaëlle | CCSD

International audience. The global replacement of histones with protamines in sperm chromatin is widespread in animals, including insects, but its actual function remains enigmatic. We show that in the Drosophila pa...

Unlocking sperm chromatin at fertilization requires a dedicated egg thioredoxin in Drosophila

Archive ouverte | Tirmarche, Samantha | CCSD

International audience. In most animals, the extreme compaction of sperm DNA is achieved after the massive replacement of histones with sperm nuclear basic proteins (SNBPs), such as protamines. In some species, the ...

Epigenetic maintenance of telomere identity in Drosophila: buckle up for the sperm ride.

Archive ouverte | Dubruille, Raphaëlle | CCSD

International audience. A critical function of telomeres is to prevent the ligation of chromosome ends by DNA repair enzymes. In most eukaryotes, telomeric DNA consists in large arrays of G-rich tandem repeats that ...

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