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Specific Mutations in the Cholesterol-Binding Site of APP Alter Its Processing and Favor the Production of Shorter, Less Toxic Aβ Peptides

Archive ouverte | Hanbouch, Linda | CCSD

International audience. Excess brain cholesterol is strongly implicated in the pathogenesis of Alzheimer’s disease (AD). Here we evaluated how the presence of a cholesterol-binding site (CBS) in the transmembrane an...

Mutating the cholesterol binding site on amyloid precursor protein alters the processing and production of Aβ-amyloid peptides

Archive ouverte | Hanbouch, L. | CCSD

International audience

MT9, a natural peptide from black mamba venom antagonizes the muscarinic type 2 receptor and reverses the M2R-agonist-induced relaxation in rat and human arteries

Archive ouverte | Ciolek, Justyna | CCSD

International audience. All five muscarinic receptors have important physiological roles. The endothelial M2 and M3 subtypes regulate arterial tone through direct coupling to Gq or Gi/o proteins. Yet, we lack select...

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