Afficher la couverture 'Localization of the Gene Encoding Peptidylglycine α-Amidating Monooxygenase (PAM) to Human Chromosome 5q14-5q21 | Ouafik, L'Houcine' en grand format
/5

0 avis

Localization of the Gene Encoding Peptidylglycine α-Amidating Monooxygenase (PAM) to Human Chromosome 5q14-5q21

Archive ouverte

Ouafik, L'Houcine | Mattei, Marie Geneviève | Giraud, Pierre | Oliver, Charles | Eipper, Betty | Mains, Richard

Edité par CCSD ; Elsevier -

International audience. Peptidylglycine alpha-amidating monooxygenase (PAM; EC 1.14.17.3) is a multifunctional protein containing two enzymes that act sequentially to catalyze the alpha-amidation of neuroendocrine peptides. Southern blot analysis of human placental DNA demonstrated that PAM is encoded by a single gene. The chromosomal localization of the PAM gene was established using in situ hybridization. A 2.2-kb human PAM cDNA hybridized to human metaphase chromosomes revealed a significant clustering of silver grains over chromosome 5 bands q14-q21. The gene encoding another enzyme important in the post-translational processing of neuroendocrine precursors, prohormone convertase 1 (PC1), is localized in the same region (5q15-q21).

Consulter en ligne

Suggestions

Du même auteur

[Role of Adrenomedullin in vasculogenesis and lymphangiogenesis: a new concept.]

Archive ouverte | Ouafik, L'Houcine | CCSD

International audience. Les mammifères possèdent deux systèmes vasculaires distincts : un réseau vasculaire sanguin essentiel à la délivrance d'oxygène et de nutriments, et un réseau vasculaire lymphatique, lequel p...

Characterization of novel mRNAs encoding enzymes involved in peptide alpha-amidation.

Archive ouverte | Stoffers, Doris A. | CCSD

International audience. The COOH-terminal alpha-amidation of bioactive peptides is a 2-step process catalyzed by two separable enzymatic activities both derived from the peptidylglycine alpha-amidating monooxygenase...

Thyroid Hormone Regulation of Peptidylglycine α-Amidating Monooxygenase Expression in Anterior Pituitary Gland

Archive ouverte | Ouafik, L'Houcine | CCSD

International audience

Chargement des enrichissements...