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α-Galactosidase/Sucrose Kinase (AgaSK), a Novel Bifunctional Enzyme from the Human Microbiome Coupling Galactosidase and Kinase Activities

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Bruel, Laëtitia | Sulzenbacher, Gerlind | Tison, Marine, Cervera | Pujol, Ange | Nicoletti, Cendrine | Perrier, Josette | Galinier, Anne | Ropartz, David | Fons, Michel | Pompeo, Frederique | Giardina, Thierry

Edité par CCSD ; American Society for Biochemistry and Molecular Biology -

International audience. Background: Raffinose, an abundant carbohydrate in plants, is degraded into galactose and sucrose by intestinal microbial enzymes. Results: AgaSK is a protein coupling galactosidase and sucrose kinase activity. The structure of the galactosidase domain sheds light onto substrate recognition. Conclusion: AgaSK produces sucrose-6-phosphate directly from raffinose. Significance: Production of sucrose-6-phosphate directly from raffinose points toward a novel glycolytic pathway in bacteria.

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