A 25-gene classifier predicts overall survival in resectable pancreatic cancer

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Birnbaum, David | Finetti, Pascal | Lopresti, Alexia | Gilabert, Marine | Poizat, Flora | Raoul, Jean-Luc | Delpero, Jean-Robert | Moutardier, Vincent | Birnbaum, Daniel | Mamessier, Emilie | Bertucci, François

Edité par CCSD ; BioMed Central -

International audience. Background: Pancreatic carcinoma is one of the most lethal human cancers. In patients with resectable tumors, surgery followed by adjuvant chemotherapy is the only curative treatment. However, the 5-year survival is 20%. Because of a strong metastatic propensity, neoadjuvant chemotherapy is being tested in randomized clinical trials. In this context, improving the selection of patients for immediate surgery or neoadjuvant chemotherapy is crucial, and high-throughput molecular analyses may help; the present study aims to address this.

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