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Antimicrobial capacity of the freshwater planarians against S-aureus is under the control of Timeless

Archive ouverte | Tsoumtsa, Landry Laure | CCSD

International audience. Planarians, which are non-parasitic flatworms, are highly resistant to bacterial infections. To better understand the mechanisms underlying this resistance, we investigated the role of the ci...

In silico analysis of Schmidtea mediterranea TIR domain-containing proteins

Archive ouverte | Tsoumtsa, Landry Laure | CCSD

International audience. While genetic evidence points towards an absence of Toll-Like Receptors (TLRs) in Platyhelminthes, the Toll/IL-1 Receptor (TIR)-domains that drive the assembly of signalling complexes downstr...

Staphylococcus aureus Promotes Smed-PGRP-2/Smed-setd8-1 Methyltransferase Signalling in Planarian Neoblasts to Sensitize Anti-bacterial Gene Responses During Re-infection

Archive ouverte | Torre, Cedric | CCSD

International audience. Little is known about how organisms exposed to recurrent infections adapt their innate immune responses. Here, we report that planarians display a form of instructed immunity to primo-infecti...

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