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Nanoscale Architecture of the Axon Initial Segment Reveals an Organized and Robust Scaffold

Archive ouverte | Leterrier, Christophe | CCSD

International audience. The axon initial segment (AIS), located within the first 30 μm of the axon, has two essential roles in generating action potentials and maintaining axonal identity. AIS assembly depends on a ...

CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment

Archive ouverte | Papandréou, Marie-Jeanne | CCSD

International audience

CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment

Archive ouverte | Papandréou, Marie-Jeanne | CCSD

International audience. The axon initial segment (AIS) plays a central role in electrogenesis and in the maintenance of neuronal polarity. Its molecular organization is dependent on the scaffolding protein ankyrin (...

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