Impact of mycotoxin on immune response and consequences for pig health

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Pierron, Alix | Alassane-Kpembi, Imourana | Oswald, Isabelle P.

Edité par CCSD -

Mycotoxins are fungal secondary metabolites detected in many agricultural commodities, especiallycereals. Due to their high consumption of cereals, pigs are exposed to these toxins. In the EuropeanUnion, regulations and/or recommendations exist in pig feed for aflatoxins, ochratoxin A, fumonisins,zearalenone, and trichothecenes, deoxynivalenol and T-2 toxin. These mycotoxins have different toxiceffects, but they all target the immune system. They have immunostimulatory or immunosuppressiveeffects depending on the toxin, the concentration and the parameter investigated. The immune system isprimarily responsible for defense against invading organisms. The consequences of the ingestion ofmycotoxin-contaminated feed are an increased susceptibility to infectious diseases, a reactivation ofchronic infection and a decreased vaccine efficacy. In this review we summarized the data available onthe effect of mycotoxins on the immune system and the consequences for pig health.

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