Afficher la couverture 'Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors | Melin, Beatrice S.' en grand format
/5

0 avis

Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

Archive ouverte

Melin, Beatrice S. | Barnholtz-Sloan, Jill S. | Wrensch, Margaret R. | Johansen, Christoffer | Il'Yasova, Dora | Kinnersley, Ben | Ostrom, Quinn T. | Labreche, Karim | Chen, Yanwen | Armstrong, Georgina | Liu, Yanhong | Eckel-Passow, Jeanette E. | Decker, Paul A. | Labussiere, Marianne | Idbaih, Ahmed | Hoang-Xuan, Khe | Di Stefano, Anna-Luisa | Mokhtari, Karima | Delattre, Jean-Yves | Broderick, Peter | Galan Hercberg, Pilar | Gousias, Konstantinos | Schramm, Johannes | Schoemaker, Minouk J. | Fleming, Sarah J. | Herms, Stefan | Heilmann, Stefanie | Noethen, Markus M. | Wichmann, Heinz-Erich | Schreiber, Stefan | Swerdlow, Anthony | Lathrop, Mark | Simon, Matthias | Sanson, Marc | Andersson, Ulrika | Rajaraman, Preetha | Chanock, Stephen | Linet, Martha | Wang, Zhaoming | Yeager, Meredith | Wiencke, John K. | Hansen, Helen | Mccoy, Lucie | Rice, Terri | Kosel, Matthew L. | Sicotte, Hugues | Amos, Christopher I. | Bernstein, Jonine L. | Davis, Faith | Lachance, Dan | Lau, Ching | Merrell, Ryan T. | Shildkraut, Joellen | Ali-Osman, Francis | Sadetzki, Siegal | Scheurer, Michael | Shete, Sanjay | Lai, Rose K. | Claus, Elizabeth B. | Olson, Sara H. | Jenkins, Robert B. | Houlston, Richard S. | Bondy, Mélissa L.

Edité par CCSD ; Nature Publishing Group -

Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 x 10(-9), odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 x 10(-10), OR = 1.24), 16p13.3 (rs2562152; P = 1.93 x 10-8, OR = 1.21), 16q12.1 (rs10852606; P = 1.29 x 10(-11), OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 x 10(-10), OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 x 10(-9), OR = 1.19), 1q44 (rs12076373; P = 2.63 x 10(-10), OR = 1.23), 2q33.3 (rs7572263; P = 2.18 x 10(-10), OR = 1.20), 3p14.1 (rs11706832; P = 7.66 x 10(-9), OR = 1.15), 10q24.33 (rs11598018; P = 3.39 x 10-8, OR = 1.14), 11q21 (rs7107785; P = 3.87 x 10(-10), OR = 1.16), 14q12 (rs10131032; P = 5.07 x 10(-11), OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 x 10(-9), OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.

Consulter en ligne

Suggestions

Du même auteur

Genome-wide association study identifies multiple susceptibility loci for glioma

Archive ouverte | Kinnersley, Ben | CCSD

International audience. Previous genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of glioma. To identify new glioma susceptibility loci, we conducted...

Deciphering the 8q24.21 association for glioma

Archive ouverte | Enciso-Mora, Victor | CCSD

International audience. We have previously identified tagSNPs at 8q24.21 influencing glioma risk. We have sought to fine-map the location of the functional basis of this association using data from four genome-wide ...

Transcriptome-Wide Association Study Identifies New Candidate Susceptibility Genes for Glioma

Archive ouverte | Atkins, Isabelle | CCSD

International audience. Genome-wide association studies (GWAS) have so far identified 25 loci associated with glioma risk, with most showing specificity for either glioblastoma (GBM) or non-GBM tumors. The majority ...

Chargement des enrichissements...