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Protein Surface and Core Dynamics Show Concerted Hydration-Dependent Activation

Archive ouverte | Wood, Kathleen | CCSD

International audience. By specifically labeling leucine/valine methyl groups and lysine side chains "inside" and "outside" dynamics of proteins on the nanosecond timescale are compared using neutron scattering. Sur...

Hydration water mobility is enhanced around tau amyloid fibers.

Archive ouverte | Fichou, Yann | CCSD

International audience. The paired helical filaments (PHF) formed by the intrinsically disordered human protein tau are one of the pathological hallmarks of Alzheimer disease. PHF are fibers of amyloid nature that a...

Mobility of a Mononucleotide within a Lipid Matrix: A Neutron Scattering Study

Archive ouverte | Misuraca, Loreto | CCSD

International audience. An essential question in studies on the origins of life is how nucleic acids were first synthesized and then incorporated into compartments about 4 billion years ago. A recent discovery is th...

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