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Deciphering Heteroresistance to Colistin in a Klebsiella pneumoniae Isolate from Marseille, France

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Bardet, Lucie | Baron, Sophie | Leangapichart, Thongpan | Okdah, Liliane | Diene, Seydina M. | Rolain, Jean-Marc | Le Page, Stephanie | Diene, Seydina, M

Edité par CCSD ; American Society for Microbiology -

International audience. Here, we report the description of a colistin-heteroresistant Klebsiella pneumoniae isolate fortuitously isolated from the stool sample of a patient with suspicion of tuberculosis in a public hospital of Marseille, France. In the colistin-resistant subpopulation, a mutation in the mgrB gene leading to a premature stop codon was found, and the hypermucoviscous phenotype was lost. Susceptibility to other antibiotics remained unchanged. To our knowledge, this is the first identification of such a colistin-heteroresistant Klebsiella pneumoniae isolate in France.

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