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Thyroid hormone triggers the developmental loss of axonal regenerative capacity via thyroid hormone receptor alpha 1 and kruppel-like factor 9 in Purkinje cells

Archive ouverte | Avci, Hasan X. | CCSD

International audience. Neurons in the CNS of higher vertebrates lose their ability to regenerate their axons at a stage of development that coincides with peak circulating thyroid hormone (T-3) levels. Here, we exa...

Mature Purkinje Cells Require the Retinoic Acid-Related Orphan Receptor-alpha (ROR alpha) to Maintain Climbing Fiber Mono-Innervation and Other Adult Characteristics

Archive ouverte | Chen, Xiao Ru | CCSD

International audience. Neuronal maturation during development is a multistep process regulated by transcription factors. The transcription factor ROR alpha (retinoic acid-related orphan receptor alpha) is necessary...

Genome-wide analysis of thyroid hormone receptors shared and specific functions in neural cells. Rôle de l’hormone thyroïdienne T3 dans la régénération axonale chez les vertébrés supérieurs

Archive ouverte | Avci, Hasan | CCSD

International audience. TRα1 and TRβ1, the two main thyroid hormone receptors in mammals, are transcription factors that share similar properties. However, their respective functions are very different. This functio...

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