Afficher la couverture 'Retinoid signaling regulates breast cancer stem cell differentiation | Ginestier, Christophe' en grand format
/5

0 avis

Retinoid signaling regulates breast cancer stem cell differentiation

Archive ouverte

Ginestier, Christophe | Wicinski, Julien | Cervera, Nathalie | Monville, Florence | Finetti, Pascal | Bertucci, François | Wicha, Max S. | Birnbaum, Daniel | Charafe-Jauffret, Emmanuelle

Edité par CCSD ; Taylor & Francis -

International audience. The cancer stem cell (CSC) hypothesis implicates the development of new therapeutic approaches to target the CSC population. Characterization of the pathways that regulate CSCs activity will facilitate the development of targeted therapies. We recently reported that the enzymatic activity of ALDH1, as measured by the ALDELFUOR assay, can be utilized to isolate normal and malignant breast stem cells in both primary tumors and cell lines. In this study, utilizing a tumorsphere assay, we have demonstrated the role of retinoid signaling in the regulation of breast CSCs self-renewal and differentiation. Utilizing the gene set enrichment analysis (GSEA) algorithm we identified gene sets and pathways associated with retinoid signaling. These pathways regulate breast CSCs biology and their inhibition may provide novel therapeutic approaches to target breast CSCs.

Consulter en ligne

Suggestions

Du même auteur

Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

Archive ouverte | Charafe-Jauffret, Emmanuelle | CCSD

International audience. Tumors may be initiated and maintained by a cellular subcomponent that displays stem cell properties. We have used the expression of aldehyde dehydrogenase as assessed by the ALDEFLUOR assay ...

Mevalonate Metabolism Regulates Basal Breast Cancer Stem Cells and Is a Potential Therapeutic Target

Archive ouverte | Ginestier, Christophe | CCSD

International audience. There is increasing evidence that breast tumors are organized in a hierarchy, with a subpopulation of tumorigenic cancer cells, the cancer stem cells (CSCs), which sustain tumor growth. The c...

ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program

Archive ouverte | Charafe-Jauffret, Emmanuelle | CCSD

International audience. Cancer stem-like cells (CSC) have been widely studied, but their clinical relevance has yet to be established in breast cancer. Here, we report the establishment of primary breast tumor-deriv...

Chargement des enrichissements...