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TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function

Archive ouverte | Merlen, Grégory | CCSD

International audience. Objective We explored the hypothesis that TGR5, the bile acid (BA) G-protein-coupled receptor highly expressed in biliary epithelial cells, protects the liver against BA overload through the ...

The P2X4 purinergic receptor regulates hepatic myofibroblast activation during liver fibrogenesis

Archive ouverte | Le Guilcher, Camille | CCSD

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TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload

Archive ouverte | Bidault-Jourdainne, Valeska | CCSD

International audience. Background & Aims: As the composition of the bile acid (BA) pool has a major impact on liver pathophysiology, we studied its regulation by the BA receptor Takeda G protein coupled receptor (T...

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