Synergistic role of calcium and vitamin D in a murine model of kidney stone disease

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Letavernier, Emmanuel | Verrier, Cécile | Goussard, Florent | Huguet, Léa | Haymann, Jean-Philippe | Baud, Laurent | Bazin, Dominique | Daudon, Michel

Edité par CCSD -

International audience. The role of vitamin D in kidney stone formation remains controversial. We analyzed whether long-term exposure of rats to vitamin D supplementation, with or without calcium-rich diet, would promote kidney stone formation or kidney tissue calcifications. Four groups of rats received vitamin D alone (100,000 UI/Kg every 3 weeks), a calcium-enriched diet alone (calcium gluconate 2g/l in drinking water), both vitamin D supplementation and calcium rich diet, or a standard diet (controls) during 6 months. Serum and urine parameters and crystalluria have been monitored during 6 months

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