Gadolinium-Based Nanoparticles and Radiation Therapy for Multiple Brain Melanoma Metastases and brain tumors: from bench to beside.

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Gadolinium-Based Nanoparticles and Radiation Therapy for Multiple Brain Melanoma Metastases and brain tumors: from bench to beside.

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International audience. More than half of all clinical cancer patients undergo radiation therapy. Besides the poor prognosis for multiple brain metastases and brain tumors, the delivery of curative radiation dose to induce tumor-kill is strongly restricted by the healthy proximal brain. We describe a nanoparticle which can act as MR contrast agent and radiosensitizer concomitantly, for the detection, monitoring and treatment of brain cancers.

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