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ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease

Archive ouverte | Letronne, Florent | CCSD

International audience. Although several ADAMs (A disintegrin-like and metalloproteases) have been shown to contribute to the amy-loid precursor protein (APP) metabolism, the full spectrum of metalloproteases involv...

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Archive ouverte | Sartori, Maxime | CCSD

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Archive ouverte | Eysert, Fanny | CCSD

International audience. Although APP metabolism is being intensively investigated, a large fraction of its modulators is yet to be characterized. In this context, we combined two genome-wide high-content screenings ...

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