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Interaction between Shadoo and PrP Affects the PrP-Folding Pathway

Archive ouverte | Ciric, Danica | CCSD

International audience. Prion diseases are characterized by conformational changes of a cellular prion protein (PrP(C)) into a β-sheet-enriched and aggregated conformer (PrP(Sc)). Shadoo (Sho), a member of the prion...

Purification and Refolding to Amyloid Fibrils of (His)-tagged Recombinant Shadoo Protein Expressed as Inclusion Bodies in [i]E. Coli[/i]

Archive ouverte | Li, Qiaojing | CCSD

The Escherichia coli expression system is a powerful tool for the production of recombinant eukaryotic proteins. We use it to produce Shadoo, a protein belonging to the prion family. A chromatographic method for the purification o...

Shadoo binds lipid membranes and undergoes aggregation and fibrillization

Archive ouverte | Li, Qiaojing | CCSD

International audience. Lipid membrane can enhance prion protein (PrP) pathological fibrillogenesis. A neuronal paralog of PrP, named Shadoo (Sho), is localized to similar membrane environment as PrP and can also co...

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