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Metabolite localization in living drosophila using High Resolution Magic Angle Spinning NMR

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Sarou-Kanian, Vincent | Joudiou, Nicolas | Louat, Fanny | Yon, Maxime | Szeremeta, Frédéric | Même, Sandra | Massiot, Dominique | Decoville, Martine | Fayon, Franck | Beloeil, Jean-Claude

Edité par CCSD ; Nature Publishing Group -

International audience. We have developed new methods enabling in vivo localization and identification of metabolites through their (1)H NMR signatures, in a drosophila. Metabolic profiles in localized regions were obtained using HR-MAS Slice Localized Spectroscopy and Chemical Shift Imaging at high magnetic fields. These methods enabled measurement of metabolite contents in anatomic regions of the fly, demonstrated by a decrease in beta-alanine signals in the thorax of flies showing muscle degeneration.

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