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Induction of the chemokine IL-8/Kc by the articular cartilage: Possible influence on osteoarthritis

Archive ouverte | Chauffier, Karine | CCSD

International audience. Purpose: IL-8 and its murine equivalent keratinocyte chemoattractant (Kc), chemokines produced by chondrocytes, contribute to the pathophysiology of osteoarthritis. However, the mechanisms le...

Stress‐induced cartilage degradation does not depend on the NLRP3 inflammasome in human osteoarthritis and mouse models

Archive ouverte | Bougault, Carole | CCSD

International audience. Objective The main feature of osteoarthritis (OA) is degradation and loss of articular cartilage. Interleukin‐1β (IL‐1β) is thought to have a prominent role in shifting the metabolic balance ...

Protective role of frizzled-related protein B on matrix metalloproteinase induction in mouse chondrocytes.

Archive ouverte | Bougault, Carole | CCSD

International audience. IntrtoductionOur objective was to investigate whether a lack of frizzled-related protein B (FrzB), an extracellular antagonist of the Wnt signaling pathways, could enhance cartilage degradati...

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