Influence of internal and outdoor factors on filamentous fungal flora in hematology wards.

Archive ouverte

Brenier-Pinchart, Marie-Pierre | Lebeau, Bernadette | Quesada, Jean-Louis | Mallaret, Marie Reine | Borel, Jean-Luc | Mollard, Annie | Garban, Frédéric | Brion, Jean-Paul | Molina, Lysiane | Bosson, Jean-Luc | Cahn, Jean-Yves | Grillot, Renée | Pelloux, Hervé

Edité par CCSD ; Elsevier -

International audience. BACKGROUND: Nosocomial invasive filamentous fungi infections could result from inhalation of filamentous fungi conidia present in hospital environment. METHODS: The environmental fungal flora in 3 different hospital wards with similar air conditioning was prospectively studied during 30 months and compared to internal (presence of agranulocytosis patient, behavioral practices, activity, cleaning work) and outdoor factors (meteorologic data, outdoor fungi). The general preventive measures differed from one unit to another. RESULTS: The hematology wards with filamentous fungi preventive measures were significantly less contaminated than a conventional ward without specific measures. Internal and outdoor factors influenced the level of fungal flora. However, the influence of internal factors was greater in the conventional ward than in hematology wards. The variation of flora in the hospital environment was seasonal, and the level of this contamination in each ward was influenced by the meteorology. However, outdoor factors more readily explain the variations of fungal load in hematology than in the conventional ward. CONCLUSION: This study highlights that specific preventive measures participate significantly in the control of the filamentous fungal flora intensity due to internal factors but not those due to outdoor factors, stressing the importance of high-efficiency particulate air filtration in high-risk units.

Consulter en ligne

Suggestions

Du même auteur

Mobile air-decontamination unit and filamentous fungal load in the hematology ward: How efficient at the low-activity mode?

Archive ouverte | Brenier-Pinchart, Marie-Pierre | CCSD

International audience. Air treatment with a mobile Plasmair air-decontamination unit significantly reduces the fungal spore load in hematology wards. We report that this system used at a low aspiration flow does no...

Diagnosis of toxoplasmosis after allogeneic stem cell transplantation: results of DNA detection and serological techniques.

Archive ouverte | Fricker-Hidalgo, Hélène | CCSD

International audience. BACKGROUND: The biological diagnosis of toxoplasmosis after allogeneic hematopoietic stem cell transplantation (HSCT) is based on the detection of Toxoplasma gondii DNA in blood specimens or ...

Phosphatidylcholine-specific phospholipase C but not gamma interferon regulate gene expression and secretion of CC Chemokine Ligand-2 (CCL-2) by human astrocytes during infection by Toxoplasma gondii.

Archive ouverte | Durand, François | CCSD

We have used human astrocytoma-derived cells to investigate the cellular responses of central nervous system cells to Toxoplasma gondii infection. At 24 h post inoculation, the secretion of CCL-2 (or Monocyte Chemotactic Protein-1...

Chargement des enrichissements...