Malnutrition and epilepsy: a two-way relationship.

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Crepin, Sabrina | Godet, Bertrand | Chassain, Benoît | Preux, Pierre-Marie | Desport, Jean-Claude

Edité par CCSD ; Elsevier / European Society for Clinical Nutrition and Metabolism -

International audience. BACKGROUND & AIMS: A link between malnutrition and epilepsy has been suspected for many years. METHODS: Different aspects of the question were studied with a review of previous published data. RESULTS: Several studies performed on animal models or humans highlight the possible adverse effects of malnutrition in the onset of seizures. Protein-energy, electrolyte, vitamin or trace element deficiencies may be involved. Conversely, several determinants of epilepsy could lead to malnutrition: food taboos and social exclusion in developing countries as well as some adverse effects of antiepileptic treatments. CONCLUSIONS: Two different hypotheses exist as a vicious circle: malnutrition predisposing to epilepsy or epilepsy predisposing to malnutrition. A better understanding of these interactions is necessary. In the mean time, malnutrition has to be prevented and treated.

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