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Dual activation of the Drosophila toll pathway by two pattern recognition receptors

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Gobert, Vanessa | Gottar, Marie | Matskevich, Alexey | Rutschmann, Sophie | Royet, Julien | Belvin, Marcia | Hoffmann, Jules | Ferrandon, Dominique

Edité par CCSD ; American Association for the Advancement of Science (AAAS) -

The Toll- dependent defense against Gram-positive bacterial infections in Drosophila is mediated through the peptidoglycan recognition protein SA (PGRP-SA). A mutation termed osiris disrupts the Gram-negative binding protein 1 ( GNBP1 ) gene and leads to compromised survival of mutant flies after Gram-positive infections, but not after fungal or Gram-negative bacterial challenge. Our results demonstrate that GNBP1 and PGRP-SA can jointly activate the Toll pathway. The potential for a combination of distinct proteins to mediate detection of infectious nonself in the fly will refine the concept of pattern recognition in insects.

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