Synthesis of the PPARbeta/delta-selective agonist GW501516 and C4-thiazole-substituted analogs.

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Synthesis of the PPARbeta/delta-selective agonist GW501516 and C4-thiazole-substituted analogs.

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Sequential, position-selective, Pd-catalyzed cross-coupling reactions of 2,4-dibromo-5-hydroxymethylthiazole provided the scaffold for the synthesis of GW501516, the most potent PPARbeta/delta agonist yet described, and equally selective analogs at the thiazole-C4 position.

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