A deficiency in RFX3 causes hydrocephalus associated with abnormal differentiation of ependymal cells.

Archive ouverte | Baas, D. | CCSD

Ciliated ependymal cells play central functions in the control of cerebrospinal fluid homeostasis in the mammalian brain, and defects in their differentiation or ciliated properties can lead to hydrocephalus. Regulatory factor X (...

Novel function of the ciliogenic transcription factor RFX3 in development of the endocrine pancreas.

Archive ouverte | Ait-Lounis, A. | CCSD

The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification

Archive ouverte | Bonnafe, E. | CCSD

International audience. There are five members of the RFX family of transcription factors in mammals. While RFX5 plays a well-defined role in the immune system, the functions of RFX1 to RFX4 remain largely unknown. ...