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Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy.

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Thijssen, Victor, L. J. L. | Postel, Ruben | Brandwijk, Ricardo, J. M. G. E. | Dings, Ruud, P. M. | Nesmelova, Irina | Satijn, Sietske | Verhofstad, Nicole | Nakabeppu, Yusaku | Baum, Linda, G. | Bakkers, Jeroen | Mayo, Kevin, H. | Poirier, Françoise | Griffioen, Arjan, W.

Edité par CCSD ; National Academy of Sciences -

International audience. We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.

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