Cytotoxic acylphenols from Myristica maingayi.

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Cytotoxic acylphenols from Myristica maingayi.

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Pham, V.C. | Jossang, A. | Sévenet, T. | Bodo, Bernard

From the cytotoxic AcOEt extract of the fruits of Myristica maingayi, a Myristicaceae, five new acylphenols (promalabaricones B and C, maingayic acids B and C, and maingayone) were isolated, together with the known malabaricones A-C. The structures were determined from spectral analysis, including mass spectrometry and 2D NMR. The cytotoxicity of the new compounds and that of malabaricones was assessed against KB cells. A biosynthetic pathway for malabaricones, via the corresponding promalabaricones as precursors, is suggested. Keywords

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