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Respiratory survival mechanisms in acetylcholinesterase knockout mouse.

Archive ouverte | Chatonnet, Fabrice | CCSD

Cholinergic neurotransmission ensures muscle contraction and plays a role in the regulation of respiratory pattern in the brainstem. Inactivation of acetylcholinesterase (AChE) by organophosphates produces respiratory failure but ...

Increased ventilation and CO2 chemosensitivity in acetylcholinesterase knockout mice.

Archive ouverte | Boudinot, Eliane | CCSD

To investigate the effects of a permanent excess of acetylcholine (AChE) on respiration, breathing and chemosensitivity were analyzed from birth to adulthood in mice lacking the AChE gene (AChE-/-), in heterozygotes, and in contro...

Effects of acetylcholinesterase and butyrylcholinesterase inhibition on breathing in mice adapted or not to reduced acetylcholinesterase.

Archive ouverte | Boudinot, Eliane | CCSD

International audience. We investigated the contributions of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition to the respiratory dysfunction produced by organophosphates in mice which were ada...

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