Influence of SNPs in nutrient-sensitive candidate genes and gene–diet interactions on blood lipids: the DiOGenes study

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Brahe, Lena | Ängquist, Lars | Larsen, Lesli | Vimaleswaran, Karani | Hager, Jörg | Viguerie, Nathalie | Loos, Ruth | Handjieva-Darlenska, Teodora | Jebb, Susan | Hlavaty, Petr | Larsen, Thomas | Martinez, J. Alfredo | Papadaki, Angeliki | Pfeiffer, Andreas | van Baak, Marleen | Sørensen, Thorkild | Holst, Claus | Langin, Dominique | Astrup, Arne | Saris, Wim

Edité par CCSD ; Cambridge University Press (CUP) -

International audience. Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene–diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP–diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP–dietary protein interaction effect on TAG was identified for lipin 1 ( LPIN1 ) rs4315495, with a decrease in TAG of − 0·26 mmol/l per A-allele/protein unit (95 % CI − 0·38, − 0·14, P = 0·000043). In conclusion, we investigated SNP–diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.

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